About this product
FOX04 5mg is supplied at 5 mg / 3 ml. [Per-product description to be added.]
Suggested use: Inject 0.1ml subq every day for 20 days
Experimental Compound: FOXO4-DRI is a research-stage senolytic peptide that has not received FDA approval. Evidence to date comes primarily from preclinical (animal) studies. Human clinical trials are limited. This page is educational. Availability is subject to physician review and applicable regulations.
What It Does
Six Reasons Researchers Are Excited About FOXO4-DRI
An experimental senolytic peptide engineered to selectively induce apoptosis in senescent "zombie" cells — the accumulated dysfunctional cells that drive inflammation, tissue degradation, and biological aging — while leaving healthy surrounding tissue completely unharmed.
Understanding Senescent "Zombie" Cells
What They Are
Damaged cells that stop dividing but refuse to die — accumulating in tissues with age and in response to stress, injury, and disease
What They Do
Secrete a toxic mixture of inflammatory cytokines (SASP) that damages neighboring healthy cells, drives chronic inflammation, and accelerates tissue aging
What FOXO4-DRI Does
Blocks the FOXO4-p53 interaction that keeps senescent cells alive — forcing them into apoptosis while leaving healthy cells completely unaffected
Selectively Eliminates Senescent Cells
FOXO4-DRI is engineered to exploit a survival mechanism unique to senescent cells. In zombie cells, FOXO4 protein binds to p53 — blocking p53's apoptosis-triggering function and keeping the cell alive despite being damaged. FOXO4-DRI disrupts this FOXO4-p53 interaction, releasing p53 to initiate programmed cell death exclusively in senescent cells. Because healthy cells do not depend on this FOXO4-p53 survival pathway, they are completely unaffected — making FOXO4-DRI a precision senolytic rather than a broadly cytotoxic agent.
Reduces Chronic Inflammation at Its Source
Senescent cells produce the senescence-associated secretory phenotype (SASP) — a sustained release of pro-inflammatory cytokines, proteases, and growth factors that damage surrounding tissue and drive systemic chronic inflammation. By eliminating senescent cells, FOXO4-DRI removes the source of this inflammatory output — producing reductions in circulating inflammatory markers that cannot be achieved through anti-inflammatory medications that merely suppress inflammation without addressing the cells generating it.
Restores Tissue Function & Regenerative Capacity
Preclinical studies in aging mice demonstrated that FOXO4-DRI treatment restored physical fitness, improved fur density, increased kidney function, and enhanced overall tissue health — reversing multiple measurable markers of biological aging. By clearing senescent cells that were occupying tissue space and suppressing stem cell activity, FOXO4-DRI appears to restore the regenerative capacity of tissues — allowing stem cells and healthy progenitors to repopulate and repair areas that were being held in inflammatory dysfunction by zombie cell accumulation.
Potential Neuroprotective & Cognitive Benefits
Senescent cells accumulate in the brain with age — particularly in microglia and astrocytes — where they drive neuroinflammation that contributes to cognitive decline and neurodegenerative disease. Senolytics that clear these cells are being actively investigated for Alzheimer's disease, Parkinson's disease, and age-related cognitive impairment. While FOXO4-DRI's CNS penetration is still being characterized, the senescent cell-clearing mechanism represents a fundamentally novel approach to addressing the neuroinflammatory component of brain aging.
Supports Musculoskeletal Health & Mobility
Senescent cells accumulate heavily in joint tissue, cartilage, and muscle — where their SASP activity drives the inflammation, cartilage degradation, and muscle fiber deterioration associated with aging and osteoarthritis. Senolytic clearance of these cells has shown significant improvements in joint function, reduced arthritic pathology, and improved muscle regenerative capacity in preclinical models. For aging individuals experiencing declining mobility and musculoskeletal health, targeting the senescent cell burden in these tissues represents a mechanistically direct intervention.
Addresses a Root Cause of Biological Aging
Cellular senescence is recognized as one of the primary hallmarks of aging — listed in the landmark "Hallmarks of Aging" framework alongside telomere attrition, epigenetic alterations, and mitochondrial dysfunction. Unlike compounds that address the downstream symptoms of aging, FOXO4-DRI targets the senescent cell accumulation that is causally upstream of multiple aging pathologies simultaneously. Clearing the senescent cell burden may produce improvements across multiple organ systems and aging markers that no single symptom-directed intervention can match.
Research Stage — Preclinical Evidence, Limited Human Data
The majority of FOXO4-DRI evidence comes from in vitro studies and animal models — particularly the landmark 2017 Nature paper by Baar et al. demonstrating senescent cell clearance and tissue restoration in aging mice. Human clinical trials are still in early stages. The mechanism is scientifically well-validated; the human clinical data is still accumulating. This compound is used in physician-supervised longevity protocols under careful clinical monitoring. Available with a valid consultation only.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Available with a valid physician consultation only.
Formulated by Dr. Sasson Moulavi
Every Lavi MD peptide is developed under the direction of Dr. Sasson Moulavi, the physician behind the brand. Formulations are built to clinical specification, not sourced from anonymous suppliers.
Dr. Moulavi earned his Doctor of Medicine from the University of Toronto and completed postgraduate training at McGill University in Montreal. He holds Board Certification in Anti-Aging Medicine and Bariatric Medicine, and is a member of the American Academy of Anti-Aging Medicine and the American Society of Bariatric Physicians. With over three decades of clinical experience in bariatric, family, and anti-aging medicine, he serves as Medical Director and prescribing physician for Lavi MD, overseeing formulation standards and clinical protocols.
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Why Lavi MD
Not All Peptide Brands Are Equal
Most peptide suppliers prioritize volume over patients. We were built differently — by a physician, for patients.
Brands / Suppliers
Medical Director on Staff
Sasson Moulavi, MD
Dispensing Physician · Chayim Therapeutics, LLC
West Palm Beach, FL
"Every product we offer is something I would prescribe to my own patients. Our formulations are designed for clinical outcomes — not marketing claims."
How We Operate
Built by a Physician, Not a Marketing Team
Lavi MD was founded under physician supervision. Every formulation, every dose, every protocol is reviewed by Dr. Moulavi before it reaches a patient — not outsourced to a contract manufacturer with no clinical input.
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American Peptide Association
The American Peptide Association is the leading industry body advancing the science, safety, and standards of peptide research. Our membership reflects our unwavering commitment to purity, transparency, and responsible sourcing — giving you full confidence in every product you purchase.
